Intracytoplasmic sperm injection (ICSI) is one of the most successful techniques of Assisted Reproductive Technology (ART) and is mostly in use for the treatment of infertility with male factors. In this method, before injecting sperm into the intracytoplasmic of the oocyte, cumulus cells around the oocyte must be stripped to facilitate the injection process. To achieve this, both enzymatic and mechanical methods are used in embryological laboratories for denudation, which has major deficiencies, including the possibility of damaging the oocyte prior to the injection process. In this research, a microfluidic-based device is introduced for the separation of cumulus cells around the oocyte with minimum manual operations. The results prove high efficiency, and non-destructive denudation of the oocyte with the reduced amount of culture medium leads to the low-cost preparation process of oocytes. The process can also be integrated with ICSI chips under development and will be reported shortly.

A B S T R A C T Considering the location of vital centers in the heart of the cities, they are more affected by unexpected events. Hence, due to the probability of the loss of existing services and devastating effects on the social organization and the necessity to prepare essential needs of people and military agencies, planning and building the storage for essential items as a replacement for the damaged services are considered a critical factor in social and defensive reliability. This research tries to locate stockpile of essential Items in Mashhad by emphasizing passive defense criteria and analyzing stockpiles of essential items in terms of form communicational structure. The type of research is applied, and the research method is in theoretical discussion and formulation of mental models, descriptive-analytical and information-gathering methods, documents, questionnaires, and interviews. Moreover, the information analysis method is with the IHWP model in GIS software in the locating section. In the section on examining architectural patterns and forms is content analysis. The research results show that 20.61 percent of Mashhad has an OPTIMAL location potential, and 0.94 percent of city also has a favorable potential for location. Also, parts of the north-east and south of the city have the priority for location. The types of spatial organization of the rectangular form, including centralized, four-armed, introverted, and diagonal, were investigated in the architecture department. The centralized form is preferable to other forms for its capacity and access to exits and spatial organization Extended Abstract Introduction As a stockpile of essential items to facilitate the process of activities and to achieve goals, the warehouse plays a vital role in creating this flexibility in organizations. In fact, from the point of view of crisis management, the stockpile of essential items can play a significant role in the supply chain to deal with unforeseen internal or external incidents. Passive defense in the stockpile of essential items refers to measures that do not require expensive and challenging methods and solutions to protect the stockpile of essential items. Furthermore, it can help avoid the substantial expenses of monitoring the entire inventory and increasing non-conformities (such as theft, fire, non-conformity in the inventory and management inspection, fatal accidents, etc.) or reduce this amount. Choosing the form of the stockpile of essential items for essential items with a passive defense approach requires a comprehensive analysis based on defense principles such as hierarchical protection, nationwide coverage, dynamic protection, relative self-sufficiency, and minimum vulnerability. Therefore, in addition to placing this category of stockpile of essential items in Mashhad, the mentioned research also tries to establish a relationship between architectural forms and principles of defense to reduce vulnerability and improve the level of relief in times of crisis.   Methodology The current type of research is applied, and the research method is descriptive-analytical. In this research, 29 people were interviewed using semi-structured questionnaires and in-depth interviews with urban and passive defense experts. The method of data analysis is quantitative and qualitative. Also, the content analysis method was used to compile and analyze the architectural forms of the stockpile of essential items of essential items compatible with the principles of passive defense. The fuzzy quantitative model IHWP was exploited in GIS software for placing the stockpile of essential items in the studied sample.   Results and discussion Locating From the overlaying of 10 indicators, distance from the fault, height of buildings, distance from gas lines, distance from high voltage power lines, road width, building density, risk of uses, distance from water transmission lines, population density, and land prone to liquefaction, location in 10 class was conducted that the first and second priority is the north-east and south of Mashhad, which has the most favorable location. In Mashhad, 17.2% of the city area has a very low score, 12.8% low score, 48.37% medium score, 20.61% high score, and 0.94% very high score regarding location desirability.   Architecture According to the previous studies on geometric forms, the suitable form for warehouse DESIGN is a simple form that does not have frequent breaks and sharp and vague points to reduce the spatial deviation. Among the geometrical shapes, square and rectangular right-cornered shapes meet the criteria of warehouse DESIGN. In the meantime, the rectangle can define joints along its length, each of which is a focal point for concentrating activities and organizing their performance. Additionally, the internal spaces in this form are reasonably defined, which results in the building's overall form being overshadowed. This also makes the surrounding accesses more targeted and focused, ultimately providing more suitable relief during times of crisis. In order to create four types of stockpiles of essential items, A (centralized), B (four arms), C (introverted), and D (polar) were DESIGNed, and the way of combining these stockpiles of essential items was expressed and analyzed separately. The research results on accesses and circulation shows that type A covers a population of over 100,000 people, which has the best performance in terms of access to exits and spatial organization and provides services in times of crisis. Therefore, type A, due to the sequence of layers, lines, and expansion on the surface, has the most functional symmetry with the body of the warehouse, and its spatial projection is limited to adapt the shell to the body. Visually, it has the least visibility from a high height. Due to its volume and formal indicators, it has a high level of homogeneity and camouflage with its surrounding environment.   Conclusion The results of placing stockpiles of essential items in Mashhad showed that the northeast and south of the city have a higher talent for establishment. According to the examination of geometric forms, the rectangular form has the most efficiency for warehouse DESIGN in the architecture area. Due to formal capabilities such as the value of lines, angles, and proportions, it has the most efficiency in terms of performance, motion circulation, and the least spatial deviation. In order to research as mentioned above, after choosing the dominant form of the rectangle, an attempt has been made to analyze the spatial organization of the rectangular form using linear, combined, decomposition, and combination methods and centripetal and radial arrangements in terms of passive defense principles. Furthermore, four different types of warehouse DESIGN were formally analyzed as patterns and representative types, which are four arms, centralized, introverted, and diagonal, each of which, in addition to functional capabilities, also covers the population's needs in crisis conditions. Finally, the concentrated type due to the extent of its successive lines and layers in close proximity to each other, the perceptibility of the surfaces of the body joints because it can be recognized from a high altitude in order not to be identified in times of crisis such as air raid, they have the highest degree of compatibility between function and form from the point of view of passive defense.   Funding There is no funding support.   Authors’ Contribution All of the authors approved the content of the manuscript and agreed on all aspects of the work.     Conflict of Interest Authors declared no conflict of interest.   Acknowledgments We are grateful to all the scientific

A novel active feedback frequency COMPENSATION SCHEME is presented in this work. Based on the proposed technique, an amplifier with two main poles in its frequency bandwidth can be easily compensated by introducing a pole-zero pair in a local feedback. The proposed method is mathematically analyzed and then based on the derived formulations, a DESIGN procedure is established. The capability of the proposed technique is examined considering a well-known two-stage amplifier, considering just a trivial modification on its input stage. To gain an analogous and fair insight, the performance of the proposed structure is compared with that is of the OPTIMALly DESIGNed millercompensated two-stage amplifier. The post-layout simulations are accomplished with TSMC 180nm CMOS standard technology. The Spectre post-layout simulations show that the proposed structure outperforms the traditional structure in terms of power consumption and gain bandwidth product. The robustness of the DESIGN is checked with Monte Carlo simulations.

In this paper, a numerical technique is proposed to solve OPTIMAL control problems (OPCs) of Volterra integral equations (VIEs). We apply the linear B-spline polynomials to solve OPCs by VIEs. The B-spline function divides the interval into sub-intervals and then built a different approximating polynomial on each sub-interval. In this method, OPTIMAL trajectory and control functions are expanded in terms of B-spline functions. The linear B-spline operational matrix of integration and multiplication are utilized in the proposed method. The main characteristic this method is that by using the suggested numerical technique and the related operational matrices, OPTIMAL control problem governed by Volterra integral equations is converted to a system of equations. Suffice it to say that this SCHEME simplifies the main problems and also makes to obtain a good approximate solution for them. In the end, there are two illustrative examples which numerical results show the validity and applicability of our method.

This paper examines in detail the little-known Friday Mosque (masjid-i jāmi‘) of Firdaus, located southwest of the Khurasan, which has had a key role in developing Saljuq architecture in the area. The original SCHEME of the mosque was unclear. The lofty īwān and two flanking dome chambers on the west (qibla) side of the courtyard are the central core of the mosque. The main aim of the article is to analyse the architecture of the mosque and demonstrate its association with the architectural style of the Saljuq mosque in the Khurasan area.  During the conservation and restoration measures in 2006, some fresh materials were unearthed. The new findings shed light on the original features of the mosque and revealed its formation. The paper describes the city's history, defines its architectural characteristics, and then analyses the present information for replying to the research questions. Owing to the outcomes of the archaeological investigation, the study suggests the general SCHEME of the mosque as a further example of the two- īwān mosque, which may be dated to the late years of the 6th /12th century. Despite the importance of the mosque, no lengthy study has been published about the building. The accurate drawing of the plan and sections of this monument, with the proposal SCHEME for the reconstruction of the mosque, are being published in this paper for the first time.

The need to improve the reliability and safety requirements, has led to increasingly utilization of reliability based DESIGN approaches. In this study, reliability based multidisciplinary DESIGN optimization for a bipropellant propulsion system has been investigated. The objective function is minimizing the total system mass and DESIGN constraints are the total impulse and the temperature of the wall of the combustion chamber. Monte Carlo simulation methodology is used to apply uncertainties in the problem and to show the reliability of the system under these uncertainties. The mass, functional and geometric results of the bipropellant propulsion system are differentiated for OPTIMAL DESIGN, reliability based DESIGN and OPTIMAL reliability based DESIGN. Then, considering the results, the concepts and definitions of DESIGN methods are compared and discussed and it is shown that the reliability based multidisciplinary optimization while having the desired mass, has high reliability.

Purpose: The science of interpretation, as the most important science responsible for understanding the Qur'an, needs to be methodized and updated so that the teachings of the Qur'an can be used easily for all classes of people. In the present study, the meaning of "future research in interpretation" is the ability to create desirable models for more efficient interpretation in the future, by using scientific tools, creativity and relying on the foundations and rules of interpretation and compensating the damages of interpretation in the past.Method: This research, with descriptive analytical method, answers the question, what are the fields and requirements of future research in interpretation? Findings: The results of the current research are based on the fact that special attention to the Qur'an, as the most important source of interpretation, rationality and methodical consideration in interpretation, attention to the prerequisites of interpretation, interpretation based on the requirements of the time, the need to pay attention to thematic interpretation, studying on the history of interpretation and observing the manners and conditions of interpretation are one of the most important requirements of interpretation in the future. Results: Considering the developments that will take place in the field of knowledge, methods and expectations from science in the future, the interpretation will also change. For this reason, in order not to cause various damages to the interpretation of the Qur'an, it is necessary to pay attention to the various contexts, principles and requirements of the interpretation of the Qur'anic commentators and scholars.